Novel insights into causal associations of body mass index or height with pneumothorax: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Observational studies have reported an association between body mass index (BMI) as well as height and the risk of pneumothorax. However, it has long been unclear whether BMI or height are causally associated with pneumothorax.

Methods

Genetic summary data for BMI, height and pneumothorax were retrieved from multiple independent large genome-wide association studies (GWAS). A series of quality control steps were conducted to select instruments. Four independent two-sample Mendelian randomization (MR) analyzes were performed to adequately assess the causal relationship between BMI or height on pneumothorax, and the robustness of the results was assessed by a series of sensitivity analyzes.

Results

Height increased the risk of pneumothorax with an OR of 1.518

SUBMITTER: Liu G 

PROVIDER: S-EPMC11298425 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature