Introducing MCC-PS: a novel prognostic score for Merkel cell carcinoma.

ABSTRACT:

Introduction

Merkel cell carcinoma (MCC) is an aggressive skin cancer with a poor prognosis, which only improved with the introduction of immunotherapies. An MCC prediction model with high diagnostic accuracy is lacking. The aim was to develop an MCC prognostic score (MCC-PS) based on combinations of previously proposed risk factors.

Methods

A multicentric, retrospective study was conducted to develop MCC-PS, which included age, neuron-specific enolase (NSE), C-reactive protein (CRP), creatinine, bilirubin, and international normalized ratio (INR). Creatinine, bilirubin, and INR were used to calculate the model of end-stage liver disease (MELD) score. A total of 98 patients were included in the study, including 36.7% with stage I according to American Joint Committee on Canc

SUBMITTER: Abu Rached N 

PROVIDER: S-EPMC11298473 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature