Genome-wide transcription response of <i>Staphylococcus epidermidis</i> to heat shock and medically relevant glucose levels.

ABSTRACT: Skin serves as both barrier and interface between body and environment. Skin microbes are intermediaries evolved to respond, transduce, or act in response to changing environmental or physiological conditions. We quantified genome-wide changes in gene expression levels for one abundant skin commensal, Staphylococcus epidermidis, in response to an internal physiological signal, glucose levels, and an external environmental signal, temperature. We found 85 of 2,354 genes change up to ~34-fold in response to medically relevant changes in glucose concentration (0-17 mM; adj p ≤0.05). We observed carbon catabolite repression in response to a range of glucose spikes, as well as upregulation of genes involved in glucose utilization in response to persistent glucose. We observ

SUBMITTER: Benjamin KN 

PROVIDER: S-EPMC11298487 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature