Sjogren's syndrome and Parkinson's disease: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Previous epidemiological studies have reported an association between Sjögren's syndrome (SS) and Parkinson's disease (PD); however, the causality and direction of this relationship remain unclear. In this study, we aimed to investigate the causal relationship between genetically determined SS and the risk of PD using bidirectional Mendelian randomization (MR).

Methods

Summary statistics for Sjögren's syndrome used as exposure were obtained from the FinnGen database, comprising 1,290 cases and 213,145 controls. The outcome dataset for PD was derived from the United Kingdom Biobank database, including 6,998 cases and 415,466 controls. Various MR methods, such as inverse variance weighted (IVW), Mendelian randomization Egger regression (MR-Egger), weighted median (W

SUBMITTER: Yin X 

PROVIDER: S-EPMC11298492 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature