Mechanically induced M2 macrophages are involved in bone remodeling of the midpalatal suture during palatal expansion.

ABSTRACT:

Background

Palatal expansion is a common way of treating maxillary transverse deficiency. Under mechanical force, the midpalatal suture is expanded, causing local immune responses. This study aimed to determine whether macrophages participate in bone remodeling of the midpalatal suture during palatal expansion and the effects on bone remodeling.

Methods

Palatal expansion model and macrophage depletion model were established. Micro-CT, histological staining, and immunohistochemical staining were used to investigate the changes in the number and phenotype of macrophages during palatal expansion as well as the effects on bone remodeling of the midpalatal suture. Additionally, the effect of mechanically induced M2 macrophages on palatal osteoblasts was also elucidated in vitro.<

SUBMITTER: Li L 

PROVIDER: S-EPMC11298508 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature