Insights into immune microenvironment and therapeutic targeting in androgen-associated prostate cancer subtypes.

ABSTRACT: Prostate cancer, one of the most prevalent malignancies among men worldwide, is intricately linked with androgen signaling, a key driver of its pathogenesis and progression. Understanding the diverse expression patterns of androgen-responsive genes holds paramount importance in unraveling the biological intricacies of this disease and prognosticating patient outcomes. In this study, utilizing consensus clustering analysis based on the expression profiles of androgen-responsive genes, prostate cancer patients from the TCGA database were stratified into two distinct subtypes, denoted as C1 and C2. Notably, the C1 subtype demonstrates a significant upregulation of certain genes, such as CGA and HSD17B12, along with a shorter progression-free survival duration, indicating a potentially unfavor

SUBMITTER: Huang L 

PROVIDER: S-EPMC11298543 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature