Enhanced vascularization and osseointegration under osteoporotic conditions through functional peptide coating on implant surfaces.

ABSTRACT: Patients with osteoporosis face challenges such as decreased bone density, a sparse trabecular structure, weakened osteogenic ability, and impaired angiogenesis, leading to poor osseointegration and implant failure. Surface modification of implants with biologically active molecules possessing various functions is an effective strategy to improve osseointegration. In this study, we constructed a simple multifunctional coating interface that significantly improves osseointegration. In brief, a multifunctional coating interface was constructed by coupling the Rgd adhesive peptide, Ogp osteogenic peptide, and Ang angiogenic peptide to Lys₆ (k₆), which self-assembled layer by layer with TA to form the (TA-Rgd@ogp@ang)n composite membrane. This study characterized the surf

SUBMITTER: Liu J 

PROVIDER: S-EPMC11298615 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature