A new crystalline daidzein-piperazine salt with enhanced solubility, permeability, and bioavailability.

ABSTRACT: To overcome the poor solubility, permeability, and bioavailability of the plant isoflavone daidzein (DAI), a novel salt of DAI with anhydrous piperazine (PIP) was obtained based on cocrystallization strategy. The new salt DAI-PIP was characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, and optical microscopy. The results showed that the maximum apparent solubility (S_max) of DAI-PIP increased by 7.27-fold and 1000-fold compared to DAI in pH 6.8 buffer and water, respectively. The peak apparent permeability coefficient (P _app ) of DAI-PIP in the Caco-2 cell model was 30.57 ± 1.08 × 10^-6 cm/s, which was 34.08% higher than that of DAI.

SUBMITTER: Meng J 

PROVIDER: S-EPMC11298695 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature