Predictive signature of murine and human host response to typical and atypical pneumonia.

ABSTRACT:

Background

Pneumonia due to typical bacterial, atypical bacterial and viral pathogens can be difficult to clinically differentiate. Host response-based diagnostics are emerging as a complementary diagnostic strategy to pathogen detection.

Methods

We used murine models of typical bacterial, atypical bacterial and viral pneumonia to develop diagnostic signatures and understand the host's response to these types of infections. Mice were intranasally inoculated with Streptococcus pneumoniae, Mycoplasma pneumoniae, influenza or saline as a control. Peripheral blood gene expression analysis was performed at multiple time points. Differentially expressed genes were used to perform gene set enrichment analysis and generate diagnostic signatures. These murine-derived si

SUBMITTER: McCravy M 

PROVIDER: S-EPMC11298752 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature