Neonatal CD8+ T Cells Resist Exhaustion during Chronic Infection.

ABSTRACT: Chronic viral infections, such as HIV and hepatitis C virus, represent a major public health problem. Although it is well understood that neonates and adults respond differently to chronic viral infections, the underlying mechanisms remain unknown. In this study, we transferred neonatal and adult CD8+ T cells into a mouse model of chronic infection (lymphocytic choriomeningitis virus clone 13) and dissected out the key cell-intrinsic differences that alter their ability to protect the host. Interestingly, we found that neonatal CD8+ T cells preferentially became effector cells early in chronic infection compared with adult CD8+ T cells and expressed higher levels of genes associated with cell migration and effector cell differentiation. During the chronic phase of infection, the neonatal c

SUBMITTER: Maymi VI 

PROVIDER: S-EPMC11298781 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature