EV-miRNAs from breast cancer patients of plasma as potential prognostic biomarkers of disease recurrence.

ABSTRACT:

Background

Extracellular vesicles (EVs), ubiquitously released by blood cells, facilitate intercellular communication. In cancer, tumor-derived EVs profoundly affect the microenvironment, promoting tumor progression and raising the risk of recurrence. These EVs contain miRNAs (EV-miRNAs), promising cancer biomarkers. Characterizing plasma EVs and identifying EV-miRNAs associated with breast cancer recurrence are crucial aspects of cancer research since they allow us to discover new biomarkers that are effective for understanding tumor biology and for being used for early detection, disease monitoring, or approaches to personalized medicine. This study aimed to characterize plasma EVs in breast cancer (BC) patients and identify EV-miRNAs associated with BC recurrence.

Methods

SUBMITTER: Causin RL 

PROVIDER: S-EPMC11298852 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature