Extracellular vesicles in anti-tumor drug resistance: Mechanisms and therapeutic prospects.

ABSTRACT: Drug resistance presents a significant challenge to achieving positive clinical outcomes in anti-tumor therapy. Prior research has illuminated reasons behind drug resistance, including increased drug efflux, alterations in drug targets, and abnormal activation of oncogenic pathways. However, there's a need for deeper investigation into the impact of drug-resistant cells on parental tumor cells and intricate crosstalk between tumor cells and the malignant tumor microenvironment (TME). Recent studies on extracellular vesicles (EVs) have provided valuable insights. EVs are membrane-bound particles secreted by all cells, mediating cell-to-cell communication. They contain functional cargoes like DNA, RNA, lipids, proteins, and metabolites from mother cells, delivered to other cells. Notably, EV

SUBMITTER: Cheng HY 

PROVIDER: S-EPMC11298875 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature