Association between body fat distribution and asthma in adults: results from the cross-sectional and bidirectional Mendelian randomization study.

ABSTRACT:

Background

Many studies define obesity based on body mass index (BMI) and explore its relationship with adult asthma. However, BMI only considers height and weight, ignoring other factors such as body fat, which may have a greater impact on health. We investigated the relationship between body fat distribution and adult asthma using both a cross-sectional study and bidirectional Mendelian randomization (MR) analysis.

Methods

Weighted logistic regression models were used to examine the relationship between body fat distribution measurements and adult asthma in the cross-sectional study from National Health and Nutrition Examination Survey (NHANES) 2011-2018. Restricted cubic spline (RCS) curves were employed to explore the dose-response relationship between them. The inverse-

SUBMITTER: Wang K 

PROVIDER: S-EPMC11299241 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature