Crossnma: An R package to synthesize cross-design evidence and cross-format data using network meta-analysis and network meta-regression.

ABSTRACT:

Background

Although aggregate data (AD) from randomised clinical trials (RCTs) are used in the majority of network meta-analyses (NMAs), other study designs (e.g., cohort studies and other non-randomised studies, NRS) can be informative about relative treatment effects. The individual participant data (IPD) of the study, when available, are preferred to AD for adjusting for important participant characteristics and to better handle heterogeneity and inconsistency in the network.

Results

We developed the R package crossnma to perform cross-format (IPD and AD) and cross-design (RCT and NRS) NMA and network meta-regression (NMR). The models are implemented as Bayesian three-level hierarchical models using Just Another Gibbs Sampler (JAGS) software within the R environment. The

SUBMITTER: Hamza T 

PROVIDER: S-EPMC11299362 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature