Exploring the causal connection: insights into diabetic nephropathy and gut microbiota from whole-genome sequencing databases.

ABSTRACT: Over recent years, the prevalence of diabetes has been on the rise, paralleling improvements in living standards. Diabetic nephropathy (DN), a prevalent complication of diabetes, has also exhibited a growing incidence. While some clinical studies and reviews have hinted at a link between diabetic nephropathy and gut microbiota (GM), the nature of this connection, specifically its causative nature, remains uncertain. Investigating the causal relationship between diabetic nephropathy and gut microbiota holds the promise of aiding in disease screening and identifying novel biomarkers. In this study, we employed a two-sample Mendelian randomization analysis. Our dataset encompassed 4,111 DN patients from the GWAS database, juxtaposed with 308,539 members forming a control group. The aim was to

SUBMITTER: Lin R 

PROVIDER: S-EPMC11299436 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature