Emerging role and the signaling pathways of uncoupling protein 2 in kidney diseases.

ABSTRACT:

Objectives

Uncoupling protein 2 (UCP2) was involved in the pathogenesis and development of kidney diseases. Many signaling pathways and factors regulate the expression of UCP2. We aimed to investigate the precise role of UCP2 and its signaling pathways in kidney diseases.

Methods

We summarized the available evidence to yield a more detailed conclusion of the signal transduction pathways of UCP2 and its role in the development and progression of kidney diseases.

Results

UCP2 could interact with 14.3.3 family proteins, mitochondrial phospholipase iPLA2γ, NMDAR, glucokinase, PPARγ2. There existed a signaling pathway between UCP2 and NMDAR, PPARγ. UCP2 can inhibit the ROS production, inflammatory response, and apoptosis, which may protect against renal injury, particularl

SUBMITTER: Mao S 

PROVIDER: S-EPMC11299446 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature