A blood-free modeling approach for the quantification of the blood-to-brain tracer exchange in TSPO PET imaging.

ABSTRACT:

Introduction

Recent evidence suggests the blood-to-brain influx rate (K₁ ) in TSPO PET imaging as a promising biomarker of blood-brain barrier (BBB) permeability alterations commonly associated with peripheral inflammation and heightened immune activity in the brain. However, standard compartmental modeling quantification is limited by the requirement of invasive and laborious procedures for extracting an arterial blood input function. In this study, we validate a simplified blood-free methodologic framework for K₁ estimation by fitting the early phase tracer dynamics using a single irreversible compartment model and an image-derived input function (1T1K-IDIF).

Methods

The method is tested on a multi-site dataset conta

SUBMITTER: Maccioni L 

PROVIDER: S-EPMC11299498 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature