Age- and Sex-Related Differences in Patients With Wild-Type Transthyretin Amyloidosis: Insights From THAOS.

ABSTRACT:

Background

Wild-type transthyretin amyloidosis (ATTRwt amyloidosis) is primarily diagnosed in elderly men but diagnoses in younger patients and women have recently increased.

Objectives

The purpose of this study was to examine age- and sex-related differences in patients with ATTRwt amyloidosis enrolled in the THAOS (Transthyretin Amyloidosis Outcomes Survey).

Methods

THAOS was a global, longitudinal, observational survey of patients with transthyretin amyloidosis, including both hereditary and wild-type disease, and asymptomatic carriers of pathogenic transthyretin gene variants. Patient characteristics at enrollment were analyzed by age at enrollment and sex (data cutoff date: August 1, 2022).

Results

Of 1,251 patients with ATTRwt amyloidosis, 13.7%, 49.1%, 3

SUBMITTER: Mora-Ayestaran N 

PROVIDER: S-EPMC11299582 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature