Quasispecies of TT virus (TTV) with sequence divergence in hypervariable regions of the capsid protein in chronic TTV infection.

ABSTRACT: Three hypervariable regions were identified in a central portion of open reading frame 1 of TT virus DNA, which codes for a putative capsid protein of 770 amino acids. TT virus circulates as quasispecies, with many amino acid substitutions in hypervariable regions, to evade immune surveillance of the hosts and to establish a persistent infection.

SUBMITTER: Nishizawa T 

PROVIDER: S-EPMC112996 | biostudies-literature | 1999 Nov

REPOSITORIES: biostudies-literature