Amplifying the electrochemical footprint of <1000 molecules in a dissolving microdroplet.

ABSTRACT: The ability of analytical strategies to detect and positively identify molecules under extremely dilute conditions is important for the growth and expansion of analytical techniques and instrumentation. At present, few measurement science techniques can robustly approach the measurement of just a few thousand molecules. Here, we present an electrochemical platform for the detection and positive identification of fewer than 1000 molecules of decamethylferrocene ((Cp*)₂Fe^II). We achieve this remarkable detection threshold by trapping (Cp*)₂Fe^II in a 1,2-dichloroethane microdroplet, which is allowed to dissolve into an aqueous continuous phase while on a gold microelectrode (radius ∼6.25 μm). Because electrochemistry is not sensitive enough to obser

SUBMITTER: Nguyen JH 

PROVIDER: S-EPMC11299638 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature