Haloarchaeal poly[(3-hydroxybutyrate)-co-(3-hydroxyvalerate)] composite films reinforced with graphene nanoplatelets as a biomaterial for skin tissue engineering.

ABSTRACT: Halophilic archaea are an untapped source for a wide range of applications. This study explores the potential of a copolymer poly[(3-hydroxybutyrate)-co-(3-hydroxyvalerate) (PHBV), naturally synthesized by the halophilic archaeon, Halogeometricum borinquense E3, as a potential candidate for a tissue engineering biomaterial. Composites and blends from natural PHBV were fabricated with poly(l-lactic acid) (PLLA), poly(ε-caprolactone) (PCL) and graphene nanoplatelets (GNP) to enhance the properties of the material. This significantly improved the tensile strength of the blend to 4.729 MPa (359%). The reinforcement with 0.3% w/v of GNP further increased the tensile strength to 13.268 MPa (981%). Characterization of the films was done using ATR-FTIR, XRD, TGA, and SEM. The haloarc

SUBMITTER: Bhende PP 

PROVIDER: S-EPMC11299771 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature