Bacteriophage-driven emergence and expansion of Staphylococcus aureus in rodent populations.

ABSTRACT: Human activities such as agriculturalization and domestication have led to the emergence of many new pathogens via host-switching events between humans, domesticated and wild animals. Staphylococcus aureus is a multi-host opportunistic pathogen with a global healthcare and economic burden. Recently, it was discovered that laboratory and wild rodents can be colonised and infected with S. aureus, but the origins and zoonotic potential of rodent S. aureus is unknown. In order to trace their evolutionary history, we employed a dataset of 1249 S. aureus genome sequences including 393 of isolates from rodents and other small mammals (including newly determined sequences for 305 isolates from 7 countries). Among laboratory mouse populations, we identified multiple widespread rodent-specific S. au

SUBMITTER: Yebra G 

PROVIDER: S-EPMC11299810 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature