Impact of waning immunity against SARS-CoV-2 severity exacerbated by vaccine hesitancy.

ABSTRACT: The SARS-CoV-2 pandemic has generated a considerable number of infections and associated morbidity and mortality across the world. Recovery from these infections, combined with the onset of large-scale vaccination, have led to rapidly-changing population-level immunological landscapes. In turn, these complexities have highlighted a number of important unknowns related to the breadth and strength of immunity following recovery or vaccination. Using simple mathematical models, we investigate the medium-term impacts of waning immunity against severe disease on immuno-epidemiological dynamics. We find that uncertainties in the duration of severity-blocking immunity (imparted by either infection or vaccination) can lead to a large range of medium-term population-level outcomes (i.e. infection c

SUBMITTER: Saad-Roy CM 

PROVIDER: S-EPMC11299835 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature