Atypical Antipsychotics and the Risk of Sudden Cardiac Death among Individuals Receiving Maintenance Hemodialysis.

ABSTRACT:

Objective

Individuals receiving hemodialysis have high rates of sudden cardiac death (SCD). This study characterized oral atypical antipsychotic use and compared the cardiac safety of atypical antipsychotics with QT prolongation FDA warnings to that of atypical antipsychotics without such warnings among outpatients receiving hemodialysis.

Methods

Data for this active-comparator, new-user cohort study were obtained from the U.S. Renal Data System (2007-2019). The primary outcome was 1-year SCD risk. Fine and Gray proportional subdistribution hazard models with inverse probability of treatment weighting were used to estimate adjusted hazard ratios (aHR) and 95% confidence intervals (CI).

Results

The quetiapine vs. atypical antipsychotic without QT prolongation wa

SUBMITTER: Nash RP 

PROVIDER: S-EPMC11299855 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature