BUILDING A DOSE TOXO-EQUIVALENCE MODEL FROM A BAYESIAN META-ANALYSIS OF PUBLISHED CLINICAL TRIALS.

ABSTRACT: In clinical practice medications are often interchanged in treatment protocols when a patient negatively reacts to their first line of therapy. Although switching between medications is common, clinicians often lack structured guidance when choosing the initial dose and frequency of a new medication, given the former with respect to risk of adverse events. In this paper we propose to establish this dose toxo-equivalence relationship using published clinical trial results with one or both drugs of interest via a Bayesian meta-analysis model that accounts for both within- and between-study variances. With the posterior parameter samples from this model, we compute median and 95% credible intervals for equivalent dose pairs of the two drugs that are predicted to produce equal rates of an adve

SUBMITTER: Sigworth EA 

PROVIDER: S-EPMC11299894 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature