Comorbidity profiling identifies potential subtype of elderly patients with nasopharyngeal carcinoma.

ABSTRACT:

Background

Few studies have assessed the comprehensive associations among comorbid diseases in elderly patients with nasopharyngeal carcinoma (NPC). This study sought to identify potential comorbidity patterns and explore the relationship of comorbidity patterns with the mortality risk in elderly patients with NPC.

Methods

A total of 452 elderly patients with NPC were enrolled in the study. The network analysis and latent class analysis were applied to mine comorbidity patterns. Propensity score matching was used for adjusting confounders. A restricted cubic spline model was used to analyze the nonlinear association between age and the risk of all-cause mortality.

Results

We identified 2 comorbidity patterns, metabolic disease-related comorbidity (MDRC) and organ dise

SUBMITTER: Li Y 

PROVIDER: S-EPMC11299953 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature