Predicting the risk of neurocognitive decline after brain irradiation in adult patients with a primary brain tumor.

ABSTRACT:

Background

Deterioration of neurocognitive function in adult patients with a primary brain tumor is the most concerning side effect of radiotherapy. This study aimed to develop and evaluate normal-tissue complication probability (NTCP) models using clinical and dose-volume measures for 6-month, 1-year, and 2-year Neurocognitive Decline (ND) postradiotherapy.

Methods

A total of 219 patients with a primary brain tumor treated with radical photon and/or proton radiotherapy (RT) between 2019 and 2022 were included. Controlled oral word association test, Hopkins verbal learning test-revised, and trail making test were used to objectively measure ND. A comprehensive set of potential clinical and dose-volume measures on several brain structures were considered for statistical model

SUBMITTER: Tohidinezhad F 

PROVIDER: S-EPMC11300005 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature