Beta-Thalassemia Major and Myocardial Iron Overload: A Longitudinal Study with Magnetic Resonance Imaging.

ABSTRACT:

Background

Patients with β-thalassemia major depend on lifelong transfusion, resulting in tissue iron overload. This longitudinal retrospective observational study aims to assess myocardial and liver iron overload using magnetic resonance imaging (MRI) and investigate the lag between myocardial and liver iron unloading in β-thalassemia patients undergoing chelation therapy.

Methods

Beta-thalassemia major patients with at least two MRI studies between 2016 and 2020 were enrolled. Myocardial and liver iron overload were defined as T2 ^∗ less than 20 and 2.1, respectively. Outcomes included mortality, myocardial and liver T2 ^∗ changes, and systolic dysfunction assessed by cardiac MRI.

Results

Fifty-five patients with a mea

SUBMITTER: Rezaei-Kalantari K 

PROVIDER: S-EPMC11300088 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature