Umami taste receptor suppresses cancer cachexia by regulating skeletal muscle atrophy in vivo and in vitro.

ABSTRACT:

Background/objectives

The umami taste receptor (TAS1R1/TAS1R3) is endogenously expressed in skeletal muscle and is involved in myogenesis; however, there is a lack of evidence about whether the expression of the umami taste receptor is involved in muscular diseases. This study aimed to elucidate the effects of the umami taste receptor and its mechanism on muscle wasting in cancer cachexia using in vivo and in vitro models.

Materials/methods

The Lewis lung carcinoma-induced cancer cachexia model was used in vivo and in vitro, and the expressions of umami taste receptor and muscle atrophy-related markers, muscle atrophy F-box protein, and muscle RING-finger protein-1 were analyzed.

Results

Results showed that TAS1R1 was significantly downregu

SUBMITTER: Lee S 

PROVIDER: S-EPMC11300116 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature