Interactions between age, sex and visceral adipose tissue on brain ageing.

ABSTRACT:

Aim

To examine the associations between visceral adipose tissue (VAT) and brain structural measures at midlife and explore how these associations may be affected by age, sex and cardiometabolic factors.

Methods

We used abdominal and brain magnetic resonance imaging data from a population-based cohort of people at midlife in the UK Biobank. Regression modelling was applied to study associations of VAT volume with total brain volume (TBV), grey matter volume (GMV), white matter volume, white matter hyperintensity volume (WMHV) and total hippocampal volume (THV), and whether these associations were altered by age, sex or cardiometabolic factors.

Results

Complete data were available for 17 377 participants (mean age 63 years, standard deviation = 12, 53% female). Greater

SUBMITTER: Moran C 

PROVIDER: S-EPMC11300145 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature