Tumors Affect the Metabolic Connectivity of the Human Brain Measured by 18 F-FDG PET.

ABSTRACT:

Purpose

18 F-FDG PET captures the relationship between glucose metabolism and synaptic activity, allowing for modeling brain function through metabolic connectivity. We investigated tumor-induced modifications of brain metabolic connectivity.

Patients and methods

Forty-three patients with left hemispheric tumors and 18 F-FDG PET/MRI were retrospectively recruited. We included 37 healthy controls (HCs) from the database CERMEP-IDB-MRXFDG. We analyzed the whole brain and right versus left hemispheres connectivity in patients and HC, frontal versus temporal tumors, active tumors versus radiation necrosis, and patients with high Karnofsky performance score (KPS = 100) versus low KPS (KPS < 70). Results were compared with 2-sided t test ( P < 0.05).

Results

Twenty high-gra

SUBMITTER: Pasquini L 

PROVIDER: S-EPMC11300165 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature