The causal association between inflammatory bowel disease and breast cancer: a bidirectional two-sample Mendelian randomization study.

ABSTRACT: Objective: This Mendelian Randomization (MR) study aims to explore the potential bidirectional causal relationship between Inflammatory Bowel Disease (IBD) and Breast Cancer (BC). Materials and Methods: We utilized genetic instruments from the summary statistics of genome-wide association studies (GWAS) on IBD among individuals of European ancestry (12,882 cases and 21,770 controls) to investigate the association with breast cancer (14,910 cases and 17,588 controls) and vice versa. The primary causal estimates were obtained using the Inverse Variance Weighting Method (IVW), and the robustness of the results was evaluated through a series of sensitivity analyses. Results: The study found a positive impact of genetically predicted IBD on breast cancer (OR = 1.047;

SUBMITTER: Yin Y 

PROVIDER: S-EPMC11300198 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature