The impacts of muscle-specific force-velocity properties on predictions of mouse muscle function during locomotion.

ABSTRACT: Introduction: The accuracy of musculoskeletal models and simulations as methods for predicting muscle functional outputs is always improving. However, even the most complex models contain various assumptions and simplifications in how muscle force generation is simulated. One common example is the application of a generalised ("generic") force-velocity relationship, derived from a limited data set to each muscle within a model, uniformly across all muscles irrespective of whether those muscles have "fast" or "slow" contractile properties. Methods: Using a previously built and validated musculoskeletal model and simulation of trotting in the mouse hindlimb, this work examines the predicted functional impact of applying muscle-specific force-velocity properties to typically fas

SUBMITTER: Charles JP 

PROVIDER: S-EPMC11300213 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature