Garlic ameliorates atherosclerosis by regulating ferroptosis pathway: an integrated strategy of network pharmacology, bioinformatic and experimental verification.

ABSTRACT:

Background

Atherosclerosis (AS) is a chronic arterial pathology and a leading cause of vascular disease-related mortality. Fatty streaks in the arterial wall develop into atherosclerosis and characteristic plaques. Clinical interventions typically involve lipid-lowering medications and drugs for stabilizing vulnerable plaques, but no direct therapeutic agent specifically targets atherosclerosis. Garlic, also locally known as DASUAN, is recognized as a widely sold herbal dietary supplement esteemed for its cardiovascular benefits. However, the specific mechanisms of garlic's anti-atherosclerotic effects remain unclear.

Aims

This study aims to elucidate the pharmacological mechanisms through which garlic ameliorates atherosclerosis.

Methods

The study identified the majo

SUBMITTER: Gao T 

PROVIDER: S-EPMC11300214 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature