Causal relationship between complement C1QB and colorectal cancer: a drug target Mendelian randomization study.

ABSTRACT:

Background

Colorectal cancer is influenced by several factors such as unhealthy habits and genetic factors. C1QB has been linked to a number of malignancies. However, uncertainty surrounds the connection between C1QB and CRC. Therefore, this study aimed to explore a bidirectional causal relationship of C1QB as a drug target in CRC through Mendelian randomization (MR) analysis.

Methods

The GWASs for C1QB and CRC were obtained from the Integrative Epidemiology Unit Open GWAS database. There were five strategies to investigate MR. Sensitivity analysis was carried out via tests for heterogeneity, horizontal pleiotropy and leave-one-out effects to evaluate the dependability of the MR analysis results. Furthermore, colocalization analysis of C1QB

SUBMITTER: Jiao M 

PROVIDER: S-EPMC11300244 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature