Polygenic scores and Mendelian randomization identify plasma proteins causally implicated in Alzheimer's disease.

ABSTRACT:

Background

An increasing body of evidence suggests that neuroinflammation is one of the key drivers of late-onset Alzheimer's disease (LOAD) pathology. Due to the increased permeability of the blood-brain barrier (BBB) in older adults, peripheral plasma proteins can infiltrate the central nervous system (CNS) and drive neuroinflammation through interactions with neurons and glial cells. Because these inflammatory factors are heritable, a greater understanding of their genetic relationship with LOAD could identify new biomarkers that contribute to LOAD pathology or offer protection against it.

Methods

We used a genome-wide association study (GWAS) of 90 different plasma proteins (n = 17,747) to create polygenic scores (PGSs) in an independent discovery (cases = 1,852 a

SUBMITTER: Cammann DB 

PROVIDER: S-EPMC11300309 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature