Intraoperative molecular imaging of colorectal lung metastases with SGM-101: a feasibility study.

ABSTRACT:

Purpose

Metastasectomy is a common treatment option for patients with colorectal lung metastases (CLM). Challenges exist with margin assessment and identification of small nodules, especially during minimally invasive surgery. Intraoperative fluorescence imaging has the potential to overcome these challenges. The aim of this study was to assess feasibility of targeting CLM with the carcinoembryonic antigen (CEA) specific fluorescent tracer SGM-101.

Methods

This was a prospective, open-label feasibility study. The primary outcome was the number of CLM that showed a true positive fluorescence signal with SGM-101. Fluorescence positive signal was defined as a signal-to-background ratio (SBR) ≥ 1.5. A secondary endpoint was the CEA expression in the colorectal lung metastases, a

SUBMITTER: Meijer RPJ 

PROVIDER: S-EPMC11300526 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature