Outpatient glucocorticoid use and COVID-19 outcomes: a population-based study.

ABSTRACT:

Introduction

Owing to controversy information surrounds effect of glucocorticoids on the evolution of COVID-19, we evaluate the effects of outpatient glucocorticoid use on the severity and progression of COVID-19 and risk of infection and analyse the effect of window of exposure and dose.

Methods

We conducted a population-based case - control study, involving 4 substudies: (i) Hospitalisation; (ii) Mortality, using subjects hospitalised with a PCR + as cases and subjects without a PCR + as controls; (iii) Progression, including subjects with a PCR + (hospitalised versus non-hospitalised); and (iv) Susceptibility, with all subjects with a PCR + and subjects without a PCR + . Adjusted odds ratios (ORa) and their 95% confidence intervals (95% CI) were calculated.

Results

SUBMITTER: Rodriguez-Fernandez A 

PROVIDER: S-EPMC11300658 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature