Epigenetic associations with neonatal age in infants born very preterm, particularly among genes involved in neurodevelopment.

ABSTRACT: The time from conception through the first year of life is the most dynamic period in human development. This time period is particularly important for infants born very preterm (< 30 weeks gestation; VPT), as they experience a significant disruption in the normal developmental trajectories and are at heightened risk of experiencing developmental impairments and delays. Variations in the epigenetic landscape during this period may reflect this disruption and shed light on the interrelationships between aging, maturation, and the epigenome. We evaluated how gestational age (GA) and age since conception in neonates [post-menstrual age (PMA)], were related to DNA methylation in buccal cells collected at NICU discharge from VPT infants (n = 538). After adjusting for confounders and applying Bo

SUBMITTER: Hodge KM 

PROVIDER: S-EPMC11300786 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature