Deep learning-based detection and semi-quantitative model for spread through air spaces (STAS) in lung adenocarcinoma.

ABSTRACT: Tumor spread through air spaces (STAS) is a distinctive metastatic pattern affecting prognosis in lung adenocarcinoma (LUAD) patients. Several challenges are associated with STAS detection, including misdetection, low interobserver agreement, and lack of quantitative analysis. In this research, a total of 489 digital whole slide images (WSIs) were collected. The deep learning-based STAS detection model, named STASNet, was constructed to calculate semi-quantitative parameters associated with STAS density and distance. STASNet demonstrated an accuracy of 0.93 for STAS detection at the tiles level and had an AUC of 0.72-0.78 for determining the STAS status at the WSI level. Among the semi-quantitative parameters, T10S, combined with the spatial location information, significantly stratified s

SUBMITTER: Feng Y 

PROVIDER: S-EPMC11300827 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature