Voxelwise analysis of the central hearing pathway in senior dogs reveals changes associated with fractional lifespan.

ABSTRACT: Presbycusis, or age-related hearing loss, affects both elderly humans and dogs, significantly impairing their social interactions and cognition. In humans, presbycusis involves changes in peripheral and central auditory systems, with central changes potentially occurring independently. While peripheral presbycusis in dogs is well-documented, research on central changes remains limited. Diffusion tensor imaging (DTI) is a useful tool for detecting and quantifying cerebral white matter abnormalities. This study used DTI to explore the central auditory pathway of senior dogs, aiming to enhance our understanding of canine presbycusis. Dogs beyond 75% of their expected lifespan were recruited and screened with brainstem auditory evoked response testing to select dogs without severe peripheral h

SUBMITTER: Yang CC 

PROVIDER: S-EPMC11300839 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature