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Chiral bifunctional sulfide-catalyzed enantioselective bromolactonizations of α- and β-substituted 5-hexenoic acids.

ABSTRACT: Enantioselective halolactonizations of sterically less hindered alkenoic acid substrates without substituents on the carbon-carbon double bond have remained a formidable challenge. To address this limitation, we report herein the asymmetric bromolactonization of 5-hexenoic acid derivatives catalyzed by a BINOL-derived chiral bifunctional sulfide.

SUBMITTER: Sumida S

PROVIDER: S-EPMC11301038 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Chiral bifunctional sulfide-catalyzed enantioselective bromolactonizations of α- and β-substituted 5-hexenoic acids.

Sumida Sao S Okuno Ken K Mori Taiki T Furuya Yasuaki Y Shirakawa Seiji S

Beilstein journal of organic chemistry 20240730

Enantioselective halolactonizations of sterically less hindered alkenoic acid substrates without substituents on the carbon-carbon double bond have remained a formidable challenge. To address this limitation, we report herein the asymmetric bromolactonization of 5-hexenoic acid derivatives catalyzed by a BINOL-derived chiral bifunctional sulfide. ...[more]

PMID: 39109297

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