A facile three-component route to powerful 5-aryldeazaalloxazine photocatalysts.

ABSTRACT: Functionalized 5-aryldeazaalloxazines have been successfully synthesised through a one-pot, three-component reaction involving N,N-dimethylbarbituric acid, an aromatic aldehyde and aniline. By utilizing readily available reagents, this approach opens up the opportunity for the efficient formation of a variety of 5-aryldeazaalloxazines bearing electron-donating or halogen groups. This practical method is characterised by atom economy and offers a direct route to the introduction of an aryl moiety into the C(5)-position of deazaalloxazines, thereby generating novel catalysts for photoredox catalysis without the need for subsequent purification. Thus, it significantly improves existing approaches.

SUBMITTER: Weisheitelova I 

PROVIDER: S-EPMC11301046 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature