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A facile three-component route to powerful 5-aryldeazaalloxazine photocatalysts.

ABSTRACT: Functionalized 5-aryldeazaalloxazines have been successfully synthesised through a one-pot, three-component reaction involving N,N-dimethylbarbituric acid, an aromatic aldehyde and aniline. By utilizing readily available reagents, this approach opens up the opportunity for the efficient formation of a variety of 5-aryldeazaalloxazines bearing electron-donating or halogen groups. This practical method is characterised by atom economy and offers a direct route to the introduction of an aryl moiety into the C(5)-position of deazaalloxazines, thereby generating novel catalysts for photoredox catalysis without the need for subsequent purification. Thus, it significantly improves existing approaches.

SUBMITTER: Weisheitelova I

PROVIDER: S-EPMC11301046 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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A facile three-component route to powerful 5-aryldeazaalloxazine photocatalysts.

Weisheitelová Ivana I Cibulka Radek R Sikorski Marek M Pavlovska Tetiana T

Beilstein journal of organic chemistry 20240731

Functionalized 5-aryldeazaalloxazines have been successfully synthesised through a one-pot, three-component reaction involving <i>N,N</i>-dimethylbarbituric acid, an aromatic aldehyde and aniline. By utilizing readily available reagents, this approach opens up the opportunity for the efficient formation of a variety of 5-aryldeazaalloxazines bearing electron-donating or halogen groups. This practical method is characterised by atom economy and offers a direct route to the introduction of an aryl ...[more]

PMID: 39109299

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