Ontology highlight
ABSTRACT:
SUBMITTER: Dolla G
PROVIDER: S-EPMC11301074 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Dolla Guillaume G Nicolas Sarah S Dos Santos Ligia Ramos LR Bourgeois Alexandre A Pardossi-Piquard Raphaëlle R Bihl Franck F Zaghrini Christelle C Justino Joana J Payré Christine C Mansuelle Pascal P Garbers Christoph C Ronco Pierre P Checler Frédéric F Lambeau Gérard G Petit-Paitel Agnès A
The Journal of biological chemistry 20240617 7
Phospholipase A2 receptor 1 (PLA2R1) is a 180-kDa transmembrane protein that plays a role in inflammation and cancer and is the major autoantigen in membranous nephropathy, a rare but severe autoimmune kidney disease. A soluble form of PLA2R1 has been detected in mouse and human serum. It is likely produced by proteolytic shedding of membrane-bound PLA2R1 but the mechanism is unknown. Here, we show that human PLA2R1 is cleaved by A Disintegrin And Metalloprotease 10 (ADAM10) and ADAM17 in HEK293 ...[more]