Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives.

ABSTRACT:

Objective

This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects.

Methods

Four HNK compounds were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization test, and conditioned location preference test were used to screen the antidepressant activity of the synthesized target compounds.

Results

In the case of 10 mg HNK treatment, compared with saline, the immobile time of mice in the HNK group, I5 group and I6 group at 1 h and 7 days had statistical significance. In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different. In the locomotor sensitization test, the movement distance o

SUBMITTER: Zang D 

PROVIDER: S-EPMC11301192 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature