Highly expressed lncRNA H19 in endometriosis promotes aerobic glycolysis and histone lactylation.

ABSTRACT:

In brief

Abnormal glucose metabolism may be involved in the pathogenesis of endometriosis. The present study identifies that highly expressed H19 leads to increased aerobic glycolysis and histone lactylation levels in endometriosis.

Abstract

Previous studies from our group and others have shown increased IncRNA H19 expression in both the eutopic endometrium and the ectopic endometriosis tissue during endometriosis. In this study, we use immunofluorescence, immunohistochemistry, and protein quantification to determine that levels of aerobic glycolysis and histone lactylation are increased in endometriosis tissues. In human endometrial stromal cells, we found that high H19 expression resulted in abnormal glucose metabolism by examining the levels of glucose, lactate, and ATP a

SUBMITTER: Wen X 

PROVIDER: S-EPMC11301422 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature