Dataset Information

Association between inflammatory biomarkers and hypertension among sedentary adults in US: NHANES 2009-2018.

ABSTRACT: Our study focuses on the relationship between inflammatory biomarkers and hypertension among sedentary adults in the United States, using data from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018. We categorized 24,614 participants into two groups based on their daily sedentary time: 9607 individuals in the sedentary group (≥7 h) and 15,007 in the non-sedentary group (<7 h). We found that the sedentary group had a significantly higher prevalence of hypertension than the non-sedentary group. Using weighted multiple logistic regression and smoothing curves, we assessed the correlation between inflammatory biomarkers and hypertension among the sedentary adults. The odds ratios for hypertension were 1.92 for the monocyte to high-density lipoprotein ratio (MHR), 1.15 for the systemic inflammation response index (SIRI), and 1.19 for the natural logarithm of the systemic immune-inflammation index (lnSII), all showing nonlinear associations. Furthermore, a significant positive correlation was found between sedentary time and inflammatory biomarkers (MHR, SIRI, and lnSII). Our findings suggest that prolonged sedentary behavior in the US significantly increases hypertension risk, likely due to marked increases in inflammation markers.

SUBMITTER: Sha S

PROVIDER: S-EPMC11301436 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Association between inflammatory biomarkers and hypertension among sedentary adults in US: NHANES 2009-2018.

Sha Shuo S Bu Xing-Peng XP Wang Ai-Wen AW Chen Huan-Zhen HZ

Journal of clinical hypertension (Greenwich, Conn.) 20240630 8

Our study focuses on the relationship between inflammatory biomarkers and hypertension among sedentary adults in the United States, using data from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018. We categorized 24,614 participants into two groups based on their daily sedentary time: 9607 individuals in the sedentary group (≥7 h) and 15,007 in the non-sedentary group (<7 h). We found that the sedentary group had a significantly higher prevalence of hypertension th ...[more]

PMID: 38946147

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Project description:PurposeSleep disorders are common globally. Probiotics may improve human microbial diversity, offering potential benefits for sleep disturbances by enhancing sleep quality and reducing disorders. We aimed to use a population-based study to investigate the association between yogurt (a probiotic food) and probiotic consumption with sleep disturbances in US adults.MethodsA total of 49,693 adults from the 2009-2018 National Health and Nutrition Examination Survey (NHANES) were included in the analyses. Sleep disorders and sleep duration were assessed according to the Sleep Disorders Questionnaire. The Dietary Questionnaire evaluated yogurt and dietary supplements containing probiotic consumption. After adjusting for confounding factors, weighted multivariable logistic regression and subgroup analyses were used to assess the association between yogurt and probiotic consumption and sleep status.ResultsOf the study cohort, 3535 (14.24 %) participants consumed yogurt and/or dietary supplements containing probiotics. The prevalence of sleep disorders was 16.22 %. Only 53.51 % of the participants achieved the recommended amount of sleep (7-9 h), with 6.10 % and 33.48 % having excessive and insufficient sleep duration, respectively. Weighted Logistic regression models indicated a significant association of probiotic intake with a decreased risk of sleep disturbances compared with those without yogurt or probiotic consumption after adjustments. (For sleep disorders: OR: 0.96, 95 % CI 0.94-0.98, P < 0.001; for sleep duration: OR: 0.98, 95 % CI 0.96-1.00, P = 0.081) Moreover, the effect size of the probiotic intake on sleep was especially significant in sex, race, and BMI subgroups.ConclusionThe present study first indicated that yogurt and probiotic consumption were associated with a reduced risk of sleep disturbances in US adults, particularly among males, whites, and those with a normal BMI. Incorporating yogurt or probiotics into the diet could serve as a public health strategy for improving sleep disturbances, though further investigation into the underlying mechanisms is needed.

Project description:ObjectivesThis study aims to investigate the association of physical activity (PA) and sedentary behaviour (SB) with chronic kidney disease (CKD), and to illustrate whether inflammatory biomarkers play a mediating role.DesignA cross-sectional study.SettingThis study analysed cross-sectional data from the National Health and Nutrition Examination Survey 2007-2018.ParticipantsA total of 27 808 participants aged 20-80 years old were enrolled in the final analysis.Outcome measuresPA and SB were self-reported by participants using the Global Physical Activity Questionnaire. Inflammatory biomarkers including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic immune inflammation index (SII) were examined in subjects' peripheral blood samples. Estimated glomerular filtration rate <60 mL/min/1.73 m2 was defined as CKD. Multivariable logistic regression and medication model were performed to examine the associations of PA, SB and inflammatory biomarkers with CKD.ResultsPA was associated with CKD, with a 20% lower OR of CKD compared with inactive (p=0.002) and a 2% lower OR per 30 min moderate-to-vigorous PA increase (p=0.027). SB was also associated with CKD, with a significant 39% higher OR for high SB (p<0.001), and a 3% higher OR per 30 min SB increase (p<0.001). NLR and SII both significantly mediated the association of PA and SB with CKD. NLR explained 1.87% (medication effect: -0.0003, direct effect: -0.0162) and 2.73% (medication effect: 0.0005, direct effect: 0.0192) association of PA and SB with CKD (p<0.001), respectively. While SII explained 1.77% (medication effect: -0.0003, direct effect: -0.0162) and 1.22% (medication effect: 0.0002, direct effect: 0.0199) association of PA and SB with CKD (p<0.001), respectively. The results did not show any statistical association between PLR and CKD in this sample.ConclusionThis finding revealed increasing PA and shortening SB may be effective strategies in CKD prevention and early management through the regulation of systemic inflammation. NLR and SII may not only be prognostic indicators of CKD, but also novel potential markers in predicting CKD occurrence.

Dataset Information

Association between inflammatory biomarkers and hypertension among sedentary adults in US: NHANES 2009-2018.

Publications

Association between inflammatory biomarkers and hypertension among sedentary adults in US: NHANES 2009-2018.

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