Regioconvergent Nucleophilic Substitutions with Morita-Baylis-Hillman Fluorides.

ABSTRACT: Lithium iodide enables regioconvergent C-F bond functionalization of isomeric Morita-Baylis-Hillman fluorides with carbon, sulfur, and nitrogen nucleophiles. The defluorinative carbon-carbon and carbon-heteroatom bond formations give multifunctional compounds in excellent yields and with good to high diastereoselectivities at room temperature. The possibility of catalytic enantioselective allylation is also discussed.

SUBMITTER: Formen JSSK 

PROVIDER: S-EPMC11301663 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature