Plasma Instead of Serum Avoids Critical Confounding of Clinical Metabolomics Studies by Platelets.

ABSTRACT: Metabolomics is an emerging and powerful bioanalytical method supporting clinical investigations. Serum and plasma are commonly used without rational prioritization. Serum is collected after blood coagulation, a complex biochemical process involving active platelet metabolism. This may affect the metabolome and increase the variance, as platelet counts and function may vary substantially in individuals. A multiomics approach systematically investigating the suitability of serum and plasma for clinical studies demonstrated that metabolites correlated well (n = 461, R² = 0.991), whereas lipid mediators (n = 83, R² = 0.906) and proteins (n = 322, R² = 0.860) differed substantially between specimen. Independently, analy

SUBMITTER: Hagn G 

PROVIDER: S-EPMC11301681 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature