Systematic Review of Randomized Clinical Trials on Direct Oral Anticoagulants in Pediatric Heart Diseases.

ABSTRACT:

Background

Direct oral anticoagulants (DOACs) have been widely applied in adults for thrombosis prophylaxis. However, the effect of DOACs in pediatric patients with congenital or acquired heart diseases who need anticoagulation therapy remains unclear.

Methods

We systematically searched the databases of PubMed, Embase, and the Cochrane Library, as well as the ClinicalTrials.gov registry and the World Health Organization's International Clinical Trials Registry Platform until June 2024 to identify relevant randomized clinical trials (RCTs). If the number of included studies was less than 5, we performed a narrative review to assess the effect of DOACs in pediatric patients.

Results

Four studies were included. In the UNIVERSE study, thrombotic events occurred in 2% of t

SUBMITTER: Guan C 

PROVIDER: S-EPMC11301724 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature